Open AccessHistoplasmosis-Associated Cross-Reactivity in the BioRad Platelia Aspergillus Enzyme Immunoassay
Author(s) -
L. Joseph Wheat,
Emily Hackett,
Michelle Durkin,
Patricia Connolly,
Rūta Petraitienė,
Thomas J. Walsh,
Kenneth S. Knox,
Chadi A. Hage
Publication year - 2007
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.00479-06
Subject(s) - immunoassay , histoplasmosis , aspergillus , enzyme , immunology , antigen , aspergillosis , microbiology and biotechnology , medicine , biology , antibody , biochemistry
We observed false-positive results in the PlateliaAspergillus enzyme-linked immunoassay (EIA) for specimens from patients with histoplasmosis and mice with experimental infection. PlateliaAspergillus EIA-positive specimens were negative in the second-generationHistoplasma antigen EIA. Care must be taken to exclude histoplasmosis for patients with positive PlateliaAspergillus EIA results.