Novel Double-Antigen Sandwich Immunoassay for Human Hepatitis B Core Antibody | Zendy

An Li | Zendy; Quan Yuan | Zendy; Zhiyin Huang | Zendy; Jian Fan | Zendy; Ruyi Guo | Zendy; Bin Lou | Zendy; Zheng Qin | Zendy; Shengxiang Ge | Zendy; Yixin Chen | Zendy; Zhijun Su | Zendy; Anthony E. T. Yeo | Zendy; Yu Chen | Zendy; Jun Zhang | Zendy; Ningshao Xia | Zendy

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Novel Double-Antigen Sandwich Immunoassay for Human Hepatitis B Core Antibody

Author(s) -

An Li,

Quan Yuan,

Zhiyin Huang,

Jian Fan,

Ruyi Guo,

Bin Lou,

Zheng Qin,

Shengxiang Ge,

Yixin Chen,

Zhijun Su,

Anthony E. T. Yeo,

Yu Chen,

Jun Zhang,

Ningshao Xia

Publication year - 2010

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00457-09

Subject(s) - immunoassay , antibody , virology , antigen , hepatitis b , immunology , medicine

A novel diagnostic immunoassay testing procedure for hepatitis B virus core antibody (anti-HBc) using homogeneous purified full-length hepatitis B virus core antigen (HBcAg) capsids obtained from Escherichia coli was compared with Abbott Architect anti-HBc chemiluminescent microparticle immunoassay (CMIA; indirect method) against a library of specimens. A monoclonal anti-HBc neutralization confirmatory assay was then used to determine the degree of discordance between specimens. The new assay was found to be superior in both sensitivity and specificity.

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