Open AccessNeedle-Free Skin Patch Delivery of a Vaccine for a Potentially Pandemic Influenza Virus Provides Protection against Lethal Challenge in Mice
Author(s) -
Sanjay Garg,
Mary A Hoelscher,
Jessica A. Belser,
Chong Wang,
Lakshmi Jayashankar,
Zhu Guo,
Ross H. Durland,
Jacqueline M. Katz,
Suryaprakash Sambhara
Publication year - 2007
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.00450-06
Subject(s) - pandemic , virology , influenza a virus subtype h5n1 , hemagglutinin (influenza) , vaccination , virus , influenza a virus , influenza vaccine , immunology , immune system , medicine , immunization , biology , covid-19 , infectious disease (medical specialty) , disease , pathology
In the event of another influenza virus pandemic, strategies for effective mass vaccination will urgently be needed. We used a novel transdermal patch delivery technology, known as the PassPort system, to vaccinate mice with recombinant H5 hemagglutinin with or without immunomodulators. This needle-free form of vaccine delivery induced robust serum antibody responses that were augmented by different immunomodulators that stimulated the innate immune system and protected mice against lethal challenge with a highly pathogenic avian H5N1 influenza virus.