Needle-Free Skin Patch Delivery of a Vaccine for a Potentially Pandemic Influenza Virus Provides Protection against Lethal Challenge in Mice | Zendy

Sanjay Garg | Zendy; Mary Hoelscher | Zendy; Jessica A. Belser | Zendy; Chong Wang | Zendy; Lakshmi Jayashankar | Zendy; Zhu Guo | Zendy; Ross H. Durland | Zendy; Jacqueline M. Katz | Zendy; Suryaprakash Sambhara | Zendy

Open Access

Needle-Free Skin Patch Delivery of a Vaccine for a Potentially Pandemic Influenza Virus Provides Protection against Lethal Challenge in Mice

Author(s) -

Sanjay Garg,

Mary Hoelscher,

Jessica A. Belser,

Chong Wang,

Lakshmi Jayashankar,

Zhu Guo,

Ross H. Durland,

Jacqueline M. Katz,

Suryaprakash Sambhara

Publication year - 2007

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00450-06

Subject(s) - pandemic , virology , influenza a virus subtype h5n1 , hemagglutinin (influenza) , vaccination , virus , influenza a virus , influenza vaccine , immunology , immune system , medicine , immunization , biology , covid-19 , infectious disease (medical specialty) , disease , pathology

In the event of another influenza virus pandemic, strategies for effective mass vaccination will urgently be needed. We used a novel transdermal patch delivery technology, known as the PassPort system, to vaccinate mice with recombinant H5 hemagglutinin with or without immunomodulators. This needle-free form of vaccine delivery induced robust serum antibody responses that were augmented by different immunomodulators that stimulated the innate immune system and protected mice against lethal challenge with a highly pathogenic avian H5N1 influenza virus.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research