Antibodies to Staphylococcus aureus Bone Sialoprotein-Binding Protein Indicate Infectious Osteomyelitis | Zendy

Lena Persson | Zendy; Christian Johansson | Zendy; Cécilia Rydèn | Zendy

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Antibodies to Staphylococcus aureus Bone Sialoprotein-Binding Protein Indicate Infectious Osteomyelitis

Author(s) -

Lena Persson,

Christian Johansson,

Cécilia Rydèn

Publication year - 2009

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00442-08

Subject(s) - bone sialoprotein , osteomyelitis , staphylococcus aureus , bone infection , serology , medicine , microbiology and biotechnology , antibody , micrococcaceae , protein a , immunology , biology , bacteria , osteocalcin , biochemistry , alkaline phosphatase , genetics , enzyme

Discrimination of soft tissue infection from osteomyelitis in diabetic foot infections is a common clinical problem.Staphylococcus aureus isolates from patients with osteomyelitis express bone sialoprotein-binding protein (Bbp) that binds the bone matrix protein bone sialoprotein. The serological assay with Bbp discriminated cases of osteomyelitis from soft tissue infections in patients with diabetic foot ulcers.

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