Open AccessAntibodies to Staphylococcus aureus Bone Sialoprotein-Binding Protein Indicate Infectious Osteomyelitis
Author(s) -
Lena Persson,
Christian Johansson,
Cecilia Rydén
Publication year - 2009
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.00442-08
Subject(s) - bone sialoprotein , osteomyelitis , staphylococcus aureus , bone infection , serology , medicine , microbiology and biotechnology , antibody , micrococcaceae , protein a , immunology , biology , bacteria , osteocalcin , biochemistry , alkaline phosphatase , genetics , enzyme
Discrimination of soft tissue infection from osteomyelitis in diabetic foot infections is a common clinical problem.Staphylococcus aureus isolates from patients with osteomyelitis express bone sialoprotein-binding protein (Bbp) that binds the bone matrix protein bone sialoprotein. The serological assay with Bbp discriminated cases of osteomyelitis from soft tissue infections in patients with diabetic foot ulcers.