Immune Complexes Isolated from Patients with Pulmonary Tuberculosis Modulate the Activation and Function of Normal Granulocytes | Zendy

Prakash Senbagavalli | Zendy; J. Nancy Hilda | Zendy; V. D. Ramanathan | Zendy; V. Kumaraswami | Zendy; Thomas B. Nutman | Zendy; Subash Babu | Zendy

Open Access

Immune Complexes Isolated from Patients with Pulmonary Tuberculosis Modulate the Activation and Function of Normal Granulocytes

Author(s) -

Prakash Senbagavalli,

J. Nancy Hilda,

V. D. Ramanathan,

V. Kumaraswami,

Thomas B. Nutman,

Subash Babu

Publication year - 2012

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00437-12

Subject(s) - chemotaxis , respiratory burst , immune system , immunology , phagocytosis , granulocyte , pathogenesis , effector , calcium , intracellular , tuberculosis , chemistry , microbiology and biotechnology , biology , medicine , biochemistry , receptor , pathology , organic chemistry

Circulating immune complexes (ICs) are associated with the pathogenesis of several diseases. Very little is known about the effect of ICs on the host immune response in patients with tuberculosis (TB). The effects of ICs isolated from patients with TB in modulating the release of calcium, cytokines, and granular proteins were studied in normal granulocytes, as were their chemotactic, phagocytic, and oxidative burst processes. ICs from TB patients induced decreased production of cytokines and platelet-activating factor (PAF) from normal granulocytes. ICs from TB patients also induced enhanced chemotaxis and phagocytosis but caused diminished oxidative burst. This was accompanied by an increased release in intracellular calcium. On the other hand, ICs from TB patients induced increased release of the granular proteins human neutrophil peptides 1 to 3 (HNP1–3). Thus, ICs from patients with TB exhibit a profound effect on granulocyte function with activation of certain effector mechanisms and dampening of others.

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