Use of Commercial Enzyme Immunoassays To Detect Antibodies to the Herpes Simplex Virus Type 2 Glycoprotein G in a Low-Risk Population in Hanoi, Vietnam | Zendy

Thoại D. Ngô | Zendy; Oliver Laeyendecker | Zendy; Hanh La | Zendy; Wayne Hogrefe | Zendy; Rhoda Ashley Morrow | Zendy; Thomas C. Quinn | Zendy

Open Access

Use of Commercial Enzyme Immunoassays To Detect Antibodies to the Herpes Simplex Virus Type 2 Glycoprotein G in a Low-Risk Population in Hanoi, Vietnam

Author(s) -

Thoại D. Ngô,

Oliver Laeyendecker,

Hanh La,

Wayne Hogrefe,

Rhoda Ashley Morrow,

Thomas C. Quinn

Publication year - 2007

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00437-06

Subject(s) - herpes simplex virus , concordance , virology , vietnamese , antibody , population , blot , biology , medicine , virus , immunology , environmental health , biochemistry , linguistics , philosophy , gene

Sera from 1,238 Vietnamese women in Hanoi were tested for herpes simplex virus type 2 (HSV-2). HSV-2 prevalence was 2.0%. The Kalon and Biokit assays showed significantly higher concordance to Western blotting data than did the Focus assay (P < 0.01). Screening by Focus and then retesting with Kalon/Biokit of positive samples can reduce falsely positive results significantly (P < 0.01).

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