Open AccessPotential Use of the Hemagglutinin-Neuraminidase Glycoprotein of Newcastle Disease Virus Expressed in Rachiplusia nu Larvae as an Immunogen for Chickens
Author(s) -
Silvina Chimeno Zoth,
Emma Laura Alfaro Gómez,
Juan Manuel Carballeda,
Oscar Taboga,
Elisa Carrillo,
Analía Berinstein
Publication year - 2009
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.00432-08
Subject(s) - immunogen , virology , newcastle disease , hemagglutinin (influenza) , biology , virus , glycoprotein , neuraminidase , recombinant dna , antibody , antigen , microbiology and biotechnology , monoclonal antibody , immunology , biochemistry , gene
The hemagglutinin-neuraminidase glycoprotein of Newcastle disease virus (NDV) was obtained as a recombinant antigen inRachiplusia nu larvae. When it was used as an immunogen in chickens, a solid immune response, including neutralizing antibodies, was detected, demonstrating the potential use of this simple and economic strategy in the design of recombinant anti-NDV vaccines.