Characterization ofPlasmodium vivaxHeat Shock Protein 70 and Evaluation of Its Value for Serodiagnosis of Tertian Malaria | Zendy

ByoungKuk Na | Zendy; Jae-Won Park | Zendy; Hyeong-Woo Lee | Zendy; Klin Lin | Zendy; SeonHee Kim | Zendy; YoungAn Bae | Zendy; WoonMok Sohn | Zendy; TongSoo Kim | Zendy; Yoon Kong | Zendy

Open Access

Characterization ofPlasmodium vivaxHeat Shock Protein 70 and Evaluation of Its Value for Serodiagnosis of Tertian Malaria

Author(s) -

ByoungKuk Na,

Jae-Won Park,

Hyeong-Woo Lee,

Klin Lin,

SeonHee Kim,

YoungAn Bae,

WoonMok Sohn,

TongSoo Kim,

Yoon Kong

Publication year - 2007

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00424-06

Subject(s) - plasmodium vivax , plasmodium falciparum , virology , malaria , antibody , recombinant dna , biology , immunoglobulin g , immunoglobulin m , immunology , biochemistry , gene

We have characterizedPlasmodium vivax heat shock protein 70 (PvHSP70) and evaluated serodiagnostic applicability of recombinant PvHSP70 (rPvHSP70). In enzyme-linked immunosorbent assays and immunoblot analyses, rPvHSP70 showed high sensitivity (88.8%; 203/228 cases).P. falciparum -infected sera revealed positive reactions (78.8%). The predominant immunoglobulin G (IgG) subclasses were segregated with IgG1 and IgG3.

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