Antibody Responses to Norovirus Genogroup GI.1 and GII.4 Proteases in Volunteers Administered Norwalk Virus | Zendy

Nadim J. Ajami | Zendy; Meagan A. Barry | Zendy; Berenice Carrillo | Zendy; Zana Muhaxhiri | Zendy; Frederick H. Neill | Zendy; B. V. Venkataram Prasad | Zendy; Antone R. Opekun | Zendy; Mark A. Gilger | Zendy; David Y. Graham | Zendy; Robert L. Atmar | Zendy; Mary K. Estes | Zendy

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Antibody Responses to Norovirus Genogroup GI.1 and GII.4 Proteases in Volunteers Administered Norwalk Virus

Author(s) -

Nadim J. Ajami,

Meagan A. Barry,

Berenice Carrillo,

Zana Muhaxhiri,

Frederick H. Neill,

B. V. Venkataram Prasad,

Antone R. Opekun,

Mark A. Gilger,

David Y. Graham,

Robert L. Atmar,

Mary K. Estes

Publication year - 2012

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00411-12

Subject(s) - norovirus , norwalk virus , virology , proteases , antibody , virus , caliciviridae , microbiology and biotechnology , biology , immunology , enzyme , biochemistry

An assay was developed to detect antibodies against two norovirus proteases among participants in a Norwalk virus (GI.1) challenge study. Prechallenge seroprevalence was lower against the protease from the homologous GI.1 virus than against protease from a heterologous GII.4 strain. Seroresponses were detected for 14 of 19 (74%) infected persons.

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