Modulation of Type 1 Diabetes Susceptibility by Tumor Necrosis Factor Alpha −308 G/A and Lymphotoxin Alpha +249 A/G Haplotypes and Lack of Linkage Disequilibrium with Predisposing DQB1-DRB1 Haplotypes in Bahraini Patients | Zendy

Mouna Stayoussef | Zendy; Fayza A. Al-Jenaidi | Zendy; Abduljabbar Al-Abbasi | Zendy; Khadija AlOla | Zendy; Haya Khayyat | Zendy; Touhami Mahjoub | Zendy; Wassim Y. Almawi | Zendy

Open Access

Modulation of Type 1 Diabetes Susceptibility by Tumor Necrosis Factor Alpha −308 G/A and Lymphotoxin Alpha +249 A/G Haplotypes and Lack of Linkage Disequilibrium with Predisposing DQB1-DRB1 Haplotypes in Bahraini Patients

Author(s) -

Mouna Stayoussef,

Fayza A. Al-Jenaidi,

Abduljabbar Al-Abbasi,

Khadija AlOla,

Haya Khayyat,

Touhami Mahjoub,

Wassim Y. Almawi

Publication year - 2007

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00410-07

Subject(s) - lymphotoxin alpha , haplotype , linkage disequilibrium , lymphotoxin , alpha (finance) , tumor necrosis factor alpha , linkage (software) , genetics , biology , beta (programming language) , type 2 diabetes , immunology , allele , endocrinology , diabetes mellitus , medicine , gene , computer science , patient satisfaction , programming language , construct validity , nursing

Tumor necrosis factor alpha (TNF-α) −308 G/A and lymphotoxin alpha (LTα) +249 A/G single-nucleotide polymorphisms were investigated in 228 type 1 diabetes mellitus (T1DM) patients and 240 controls. Only LTα +249G allele and +249G/+249G genotype frequencies were higher among patients, and no linkage disequilibrium was found between TNF-α/LTα alleles and susceptible/protectiveDRB1-DQB1 haplotypes. TNF-α/LTα T1DM-susceptible (−308G/+249G) and protective (−308G/+249A) haplotypes were identified.

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