OspC Phylogenetic Analyses Support the Feasibility of a Broadly Protective Polyvalent Chimeric Lyme Disease Vaccine | Zendy

Christopher G. Earnhart | Zendy; Richard T. Marconi | Zendy

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OspC Phylogenetic Analyses Support the Feasibility of a Broadly Protective Polyvalent Chimeric Lyme Disease Vaccine

Author(s) -

Christopher G. Earnhart,

Richard T. Marconi

Publication year - 2007

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00409-06

Subject(s) - lyme disease , phylogenetic tree , biology , virology , borrelia burgdorferi , antigen , computational biology , microbiology and biotechnology , genetics , antibody , gene

Using availableBorrelia outer surface protein C (OspC) sequences, a phylogenetic analysis was undertaken to delineate the number of antigenic domains required for inclusion in a broadly protective, chimeric, OspC-based Lyme disease vaccine. The data indicate that approximately 34 would be required and that an OspC-based vaccinogen is feasible.

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