Role of Defective Thymic Function in Onset of Ganciclovir-Resistant Cytomegalovirus after Cord Blood Transplantation | Zendy

Sara Cantisán | Zendy; Carmen Martín | Zendy; María Concepción Romero-Sánchez | Zendy; Sara FerrandoMartínez | Zendy; Francisco Martínez | Zendy; Antonio Rivero | Zendy; Antonio Torres | Zendy; Rafael Solana | Zendy; Julián TorreCisneros | Zendy

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Role of Defective Thymic Function in Onset of Ganciclovir-Resistant Cytomegalovirus after Cord Blood Transplantation

Author(s) -

Sara Cantisán,

Carmen Martín,

María Concepción Romero-Sánchez,

Sara FerrandoMartínez,

Francisco Martínez,

Antonio Rivero,

Antonio Torres,

Rafael Solana,

Julián TorreCisneros

Publication year - 2012

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00407-12

Subject(s) - valganciclovir , ganciclovir , cytomegalovirus , immunology , cord blood , transplantation , herpesviridae , biology , medicine , human cytomegalovirus , virology , virus , viral disease

A case of recurrent cytomegalovirus reactivations in a cytomegalovirus-seropositive woman who received allogeneic cord blood transplantation is described. Thirteen months posttransplantation, her CD3+ T cell count was extremely low whereas natural killer cells represented 66% of her total lymphocytes. She showed defective thymic function that might contribute to the onset of valganciclovir resistance.

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