High Seroprevalence of Neutralizing Capacity against Human Metapneumovirus in All Age Groups Studied in Bonn, Germany | Zendy

Jessica Lüsebrink | Zendy; C.H.R. Wiese | Zendy; Anne Thiel | Zendy; Ramona-Liza Tillmann | Zendy; Vanessa Ditt | Zendy; Andreas Müller | Zendy; Oliver Schildgen | Zendy; Verena Schildgen | Zendy

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High Seroprevalence of Neutralizing Capacity against Human Metapneumovirus in All Age Groups Studied in Bonn, Germany

Author(s) -

Jessica Lüsebrink,

C.H.R. Wiese,

Anne Thiel,

Ramona-Liza Tillmann,

Vanessa Ditt,

Andreas Müller,

Oliver Schildgen,

Verena Schildgen

Publication year - 2009

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00398-09

Subject(s) - human metapneumovirus , seroprevalence , metapneumovirus , virology , immunology , antibody , medicine , biology , respiratory tract infections , respiratory system , serology

Human metapneumovirus (hMPV) infections occur frequently despite high rates of perpetual seroprevalence for all age groups. Analyses of ∼2,000 archived, randomly selected serum samples demonstrated that neutralizing capacities remain high, with a minor decrease for individuals over 69 years of age, leading to the hypothesis that reinfections occur because humoral immune responses play minor roles in the clearance of hMPV infections.

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