Open AccessHigh Seroprevalence of Neutralizing Capacity against Human Metapneumovirus in All Age Groups Studied in Bonn, Germany
Author(s) -
Jessica Lüsebrink,
C.H.R. Wiese,
Anne Thiel,
Ramona-Liza Tillmann,
Vanessa Ditt,
Andreas Müller,
Oliver Schildgen,
Verena Schildgen
Publication year - 2010
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.00398-09
Subject(s) - human metapneumovirus , seroprevalence , metapneumovirus , virology , immunology , antibody , medicine , biology , respiratory tract infections , respiratory system , serology
Human metapneumovirus (hMPV) infections occur frequently despite high rates of perpetual seroprevalence for all age groups. Analyses of ∼2,000 archived, randomly selected serum samples demonstrated that neutralizing capacities remain high, with a minor decrease for individuals over 69 years of age, leading to the hypothesis that reinfections occur because humoral immune responses play minor roles in the clearance of hMPV infections.