Open AccessIncreasing Incidence of Streptococcus pneumoniae Serotype 19A and Emergence of Two Vaccine Escape Recombinant ST695 Strains in Liguria, Italy, 7 Years after Implementation of the 7-Valent Conjugated Vaccine
Author(s) -
Filippo Ansaldi,
Paola Canepa,
Daniela de Florentiis,
Roberto Bandettini,
Paolo Durando,
Giancarlo Icardi
Publication year - 2011
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.00383-10
Subject(s) - serotype , streptococcus pneumoniae , virology , incidence (geometry) , recombinant dna , microbiology and biotechnology , pneumococcal infections , biology , antibiotics , physics , gene , biochemistry , optics
Two serotype 19A (ST695) Streptococcus pneumoniae vaccine escape recombinant strains attributable to capsular switching events were detected by a laboratory surveillance system that is an integral part of a vaccination program begun in Liguria, Italy, in May 2003, an Italian administrative region with long-lasting high coverage, an unusual occurrence in Europe. To our knowledge, this is the first detection of an occurrence of capsular switching outside the United States.