Open AccessCytokines across the Night in Chronic Fatigue Syndrome with and without Fibromyalgia
Author(s) -
Tôru Nakamura,
Stephan Schwander,
Robert Donnelly,
Félix Zurita Ortega,
Fumiharu Togo,
Gordon Broderick,
Yoshiharu Yamamoto,
Neil S. Cherniack,
David M. Rapoport,
Benjamin H. Natelson
Publication year - 2010
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.00379-09
Subject(s) - proinflammatory cytokine , chronic fatigue syndrome , fibromyalgia , cytokine , immune system , immunology , sleep deprivation , medicine , immune dysfunction , interleukin 6 , downregulation and upregulation , sickness behavior , inflammation , circadian rhythm , biology , biochemistry , gene
The symptoms of chronic fatigue syndrome (CFS) are consistent with cytokine dysregulation. This has led to the hypothesis of immune dysregulation as the cause of this illness. To further test this hypothesis, we did repeated blood sampling for cytokines while patients and matched healthy controls slept in the sleep lab. Because no one method for assaying cytokines is acknowledged to be better than another, we assayed for protein in serum, message in peripheral blood lymphocytes (PBLs), and function in resting and stimulated PBLs. We found no evidence of proinflammatory cytokine upregulation. Instead, in line with some of our earlier studies, we did find some evidence to support a role for an increase in interleukin-10, an anti-inflammatory cytokine. Although the changes were small, they may contribute to the common complaint in CFS patients of disrupted sleep.