Elimination of False-Positive Results in a Luminex Assay for Pneumococcal Antibodies | Zendy

Jerry W. Pickering | Zendy; Matthew T. Larson | Zendy; Thomas B. Martins | Zendy; Susan S. Copple | Zendy; Harry R. Hill | Zendy

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Elimination of False-Positive Results in a Luminex Assay for Pneumococcal Antibodies

Author(s) -

Jerry W. Pickering,

Matthew T. Larson,

Thomas B. Martins,

Susan S. Copple,

Harry R. Hill

Publication year - 2009

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00329-09

Subject(s) - antibody , bovine serum albumin , streptococcus pneumoniae , medicine , immunology , virology , chemistry , microbiology and biotechnology , biology , antibiotics

In our 14-valent Luminex assay for pneumococcal antibodies, we identified two groups of sera that caused false-positive results. The first group bound nonspecifically to the Luminex microspheres. The second group reacted specifically with bovine serum albumin (BSA). We describe here methods that eliminated the false-positive reactivity of both groups.

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