Additional Diagnostic Yield of Adding Serology to PCR in Diagnosing Viral Acute Respiratory Infections in Kenyan Patients 5 Years of Age and Older | Zendy

Daniel R. Feikin | Zendy; M. Kariuki Njenga | Zendy; Godfrey Bigogo | Zendy; Barrack Aura | Zendy; Stella Gikunju | Zendy; Amanda Balish | Zendy; Mark A. Katz | Zendy; Dean D. Erdman | Zendy; Robert F. Breiman | Zendy

Open Access

Additional Diagnostic Yield of Adding Serology to PCR in Diagnosing Viral Acute Respiratory Infections in Kenyan Patients 5 Years of Age and Older

Author(s) -

Daniel R. Feikin,

M. Kariuki Njenga,

Godfrey Bigogo,

Barrack Aura,

Stella Gikunju,

Amanda Balish,

Mark A. Katz,

Dean D. Erdman,

Robert F. Breiman

Publication year - 2012

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00325-12

Subject(s) - serology , kenya , medicine , immunology , virology , respiratory system , covid-19 , intensive care medicine , biology , antibody , disease , infectious disease (medical specialty) , ecology

The role of serology in the setting of PCR-based diagnosis of acute respiratory infections (ARIs) is unclear. We found that acute- and convalescent-phase paired-sample serologic testing increased the diagnostic yield of naso/oropharyngeal swabs for influenza virus, respiratory syncytial virus (RSV), human metapneumovirus, adenovirus, and parainfluenza viruses beyond PCR by 0.4% to 10.7%. Although still limited for clinical use, serology, along with PCR, can maximize etiologic diagnosis in epidemiologic studies.

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