Open AccessImmunologic Paradox in the Diagnosis of Tuberculous Meningitis
Author(s) -
Sung-Han Kim,
Yang Soo Kim
Publication year - 2009
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.00321-09
Subject(s) - tuberculous meningitis , mycobacterium tuberculosis , immunology , tuberculosis , cerebrospinal fluid , meningitis , medicine , differential diagnosis , pathology , pediatrics
We report a patient with microbiologically documented tuberculous meningitis showing that the therapeutic paradox, a therapy-induced switch to a neutrophil-predominant situation in the differential cell counts of cerebrospinal fluid specimens, had a correlation with an immunologic paradox, an increasedMycobacterium tuberculosis -specific gamma interferon-producing T-cell response.