Open AccessMonocyte-Derived Interleukin-10 Depresses the Bordetella pertussis - Specific Gamma Interferon Response in Vaccinated Infants
Author(s) -
Violette Dirix,
Virginie Verscheure,
Tessa Goetghebuer,
Marc Hainaut,
Anne-Sophie Debrie,
Camille Locht,
Françoise Mascart
Publication year - 2009
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.00314-09
Subject(s) - bordetella pertussis , monocyte , interferon gamma , immunology , microbiology and biotechnology , whooping cough , interferon , pertussis vaccine , virology , biology , medicine , cytokine , vaccination , immune system , immunization , bacteria , genetics
Antigen-specific gamma interferon (IFN-gamma) has been demonstrated to participate in protection against Bordetella pertussis infection. Circulating mononuclear cells from B. pertussis-infected and from pertussis-vaccinated infants secrete high amounts of IFN-gamma after in vitro stimulation by B. pertussis antigens, but with a large variation in the secreted IFN-gamma levels between individuals. We show here that the inhibition of the specific IFN-gamma response can be at least partially attributed to IL-10 secretion by monocytes. This IL-10 secretion was not associated with polymorphisms at positions -1082, -819, and -592 of the IL-10 gene promoter, suggesting that other genetic or environmental factors affect IL-10 expression and secretion.