Monocyte-Derived Interleukin-10 Depresses the Bordetella pertussis - Specific Gamma Interferon Response in Vaccinated Infants | Zendy

Violette Dirix | Zendy; Virginie Verscheure | Zendy; Tessa Goetghebuer | Zendy; Marc Hainaut | Zendy; AnneSophie Debrie | Zendy; Camille Locht | Zendy; Françoise Mascart | Zendy

Open Access

Monocyte-Derived Interleukin-10 Depresses the Bordetella pertussis - Specific Gamma Interferon Response in Vaccinated Infants

Author(s) -

Violette Dirix,

Virginie Verscheure,

Tessa Goetghebuer,

Marc Hainaut,

AnneSophie Debrie,

Camille Locht,

Françoise Mascart

Publication year - 2009

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00314-09

Subject(s) - bordetella pertussis , monocyte , interferon gamma , immunology , microbiology and biotechnology , whooping cough , interferon , pertussis vaccine , virology , biology , medicine , cytokine , vaccination , immune system , immunization , bacteria , genetics

Antigen-specific gamma interferon (IFN-gamma) has been demonstrated to participate in protection against Bordetella pertussis infection. Circulating mononuclear cells from B. pertussis-infected and from pertussis-vaccinated infants secrete high amounts of IFN-gamma after in vitro stimulation by B. pertussis antigens, but with a large variation in the secreted IFN-gamma levels between individuals. We show here that the inhibition of the specific IFN-gamma response can be at least partially attributed to IL-10 secretion by monocytes. This IL-10 secretion was not associated with polymorphisms at positions -1082, -819, and -592 of the IL-10 gene promoter, suggesting that other genetic or environmental factors affect IL-10 expression and secretion.

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