Development of a Rapid and Convenient Method for Determination of Rubella Virus-Specific Immunoglobulin G Avidity | Zendy

Christelle VauloupFellous | Zendy; Jessica Ursulet-Diser | Zendy; L. GrangeotKeros | Zendy

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Development of a Rapid and Convenient Method for Determination of Rubella Virus-Specific Immunoglobulin G Avidity

Author(s) -

Christelle VauloupFellous,

Jessica Ursulet-Diser,

L. GrangeotKeros

Publication year - 2007

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00312-07

Subject(s) - avidity , rubella virus , rubella , immunoglobulin g , virology , antibody , specific antibody , computer science , immunology , biology , vaccination , measles

We describe here a rapid and semiautomated method for the determination of rubella virus immunoglobulin G (IgG) avidity with the VIDAS instrument. A total of 153 serum samples from persons with naturally acquired rubella virus infections (n = 98), from vaccinated persons (n = 44), and from patients with autoantibodies (n = 11) were included in this study. The rubella virus-specific IgG avidity assay we developed for the VIDAS instrument was evaluated by comparison with an in-house method. Results obtained with the VIDAS instrument allow considering this method valuable to help confirm or exclude acute primary infection or recent vaccination.

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