Evaluation of Immunostimulatory Activities of Synthetic Mannose-Containing Structures Mimicking the β-(1→2)-Linked Cell Wall Mannans of Candida albicans | Zendy

Kaarina Ranta | Zendy; Kaisa Nieminen | Zendy; Filip S. Ekholm | Zendy; Monika Poláková | Zendy; Mattias U. Roslund | Zendy; Tiina Saloranta | Zendy; Reko Leino | Zendy; J. Savolainen | Zendy

Open Access

Evaluation of Immunostimulatory Activities of Synthetic Mannose-Containing Structures Mimicking the β-(1→2)-Linked Cell Wall Mannans of Candida albicans

Author(s) -

Kaarina Ranta,

Kaisa Nieminen,

Filip S. Ekholm,

Monika Poláková,

Mattias U. Roslund,

Tiina Saloranta,

Reko Leino,

J. Savolainen

Publication year - 2012

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00298-12

Subject(s) - candida albicans , mannose , peripheral blood mononuclear cell , tumor necrosis factor alpha , in vitro , interferon gamma , microbiology and biotechnology , chemistry , disaccharide , biochemistry , biology , immunology

Immunostimulatory properties of synthetic structures mimicking the β-(1→2)-linked mannans of Candida albicans were evaluated in vitro . Contrary to earlier observations, tumor necrosis factor (TNF) production was not detected after stimulation with mannotetraose in mouse macrophages. Divalent disaccharide 1,4-bis(α- d -mannopyranosyloxy)butane induced TNF and some molecules induced low levels of gamma interferon (IFN-γ) in human peripheral blood mononuclear cells (PBMC).

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