Enzyme-Linked Immunosorbent Assay Method for Detection of Cytomegalovirus Strain-Specific Antibody Responses | Zendy

Zdeněk Novák | Zendy; Shan Ross | Zendy; A. Raj Kumar Patro | Zendy; Sunil Pati | Zendy; Meera K. Reddy | Zendy; Misty Purser | Zendy; William J. Britt | Zendy; Suresh B. Boppana | Zendy

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Enzyme-Linked Immunosorbent Assay Method for Detection of Cytomegalovirus Strain-Specific Antibody Responses

Author(s) -

Zdeněk Novák,

Shan Ross,

A. Raj Kumar Patro,

Sunil Pati,

Meera K. Reddy,

Misty Purser,

William J. Britt,

Suresh B. Boppana

Publication year - 2008

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00281-08

Subject(s) - cytomegalovirus , serology , antibody , virology , epitope , glycoprotein , human cytomegalovirus , enzyme , biology , microbiology and biotechnology , herpesviridae , immunology , virus , viral disease , biochemistry

Reliable methods for the detection of cytomegalovirus (CMV) strain-specific serological responses are lacking. We describe a simple and reliable enzyme-linked immunosorbent assay method developed to detect antibodies against the polymorphic epitopes within the two envelope glycoproteins of CMV, glycoproteins H and B. This assay is useful for the detection of serologic responses to CMV strains and the identification of CMV reinfections.

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