Western Blotting Is an Efficient Tool for Differential Diagnosis of Paracoccidioidomycosis and Pulmonary Tuberculosis | Zendy

Thâmara Aline Bertoni | Zendy; Maysa Cláudia Zolin Perenha-Viana | Zendy; Eliana Valéria Patussi | Zendy; Rosilene Fressatti Cardoso | Zendy; Terezinha Inez Estivalet Svidzinski | Zendy

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Western Blotting Is an Efficient Tool for Differential Diagnosis of Paracoccidioidomycosis and Pulmonary Tuberculosis

Author(s) -

Thâmara Aline Bertoni,

Maysa Cláudia Zolin Perenha-Viana,

Eliana Valéria Patussi,

Rosilene Fressatti Cardoso,

Terezinha Inez Estivalet Svidzinski

Publication year - 2012

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00252-12

Subject(s) - paracoccidioidomycosis , tuberculosis , differential diagnosis , sputum , medicine , antibody , blot , pulmonary tuberculosis , immunology , pathology , biology , biochemistry , gene

Sputum and sera from 134 patients screened for tuberculosis (TB) were analyzed to investigate TB and paracoccidioidomycosis (PCM). Of these patients, 11 (8.2%) were confirmed to have TB, but six (4.5%) were positive only for PCM. All patients with PCM presented anti-43-kDa-component antibodies in Western blotting (WB) assays, while in the TB-positive patients these antibodies did not appear. This preliminary study suggests WB as a potential tool for differential laboratory diagnosis between TB and PCM.

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