Antibodies Induced by Dengue Virus Type 1 and 2 Envelope Domain III Recombinant Proteins in Monkeys Neutralize Strains with Different Genotypes | Zendy

Lídice Bernardo | Zendy; Osmel Fleitas | Zendy; Alequis Pavón | Zendy; Lisset Hermida | Zendy; Gerardo Guillén | Zendy; María G. Guzmán | Zendy

Open Access

Antibodies Induced by Dengue Virus Type 1 and 2 Envelope Domain III Recombinant Proteins in Monkeys Neutralize Strains with Different Genotypes

Author(s) -

Lídice Bernardo,

Osmel Fleitas,

Alequis Pavón,

Lisset Hermida,

Gerardo Guillén,

María G. Guzmán

Publication year - 2009

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00191-09

Subject(s) - virology , dengue virus , recombinant dna , antibody dependent enhancement , dengue fever , virus , neutralizing antibody , biology , antibody , titer , genotype , flavivirus , gene , immunology , genetics

In the present work, we evaluated the neutralizing capacity of the antibodies induced by dengue virus type 1 and 2 envelope domain III recombinant proteins in monkeys against strains of different dengue virus type 1 and 2 genotypes. Here we demonstrated that dengue virus type 1 and 2 recombinant proteins induced high titers of neutralizing antibodies against different genotype strains.

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