Open AccessAntibodies Induced by Dengue Virus Type 1 and 2 Envelope Domain III Recombinant Proteins in Monkeys Neutralize Strains with Different Genotypes
Author(s) -
Lídice Bernardo,
Osmel Fleitas,
Alequis Pavón,
Lisset Hermida,
Gerardo Guillén,
María G. Guzmán
Publication year - 2009
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.00191-09
Subject(s) - virology , dengue virus , recombinant dna , antibody dependent enhancement , dengue fever , virus , neutralizing antibody , biology , antibody , titer , genotype , flavivirus , gene , immunology , genetics
In the present work, we evaluated the neutralizing capacity of the antibodies induced by dengue virus type 1 and 2 envelope domain III recombinant proteins in monkeys against strains of different dengue virus type 1 and 2 genotypes. Here we demonstrated that dengue virus type 1 and 2 recombinant proteins induced high titers of neutralizing antibodies against different genotype strains.