Protective Effect of Human Heat Shock Protein 60 Suggested by Its Association with Decreased Seropositivity to Pathogens | Zendy

Andrew Steptoe | Zendy; Alireza ShamaeiTousi | Zendy; Alexandra E. Gylfe | Zendy; Leslie Bailey | Zendy; Sven Bergström | Zendy; Anthony Coates | Zendy; Brian E. Henderson | Zendy

Open Access

Protective Effect of Human Heat Shock Protein 60 Suggested by Its Association with Decreased Seropositivity to Pathogens

Author(s) -

Andrew Steptoe,

Alireza ShamaeiTousi,

Alexandra E. Gylfe,

Leslie Bailey,

Sven Bergström,

Anthony Coates,

Brian E. Henderson

Publication year - 2007

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00179-06

Subject(s) - hsp60 , heat shock protein , shock (circulatory) , immunology , disease , association (psychology) , biology , medicine , hsp70 , psychology , biochemistry , gene , psychotherapist

The presence of heat shock protein 60 (Hsp60) in human plasma has been linked with cardiovascular disease (CVD). In this study, the examination of the relationship between Hsp60 in plasma and seropositivity for three microbial agents, which are thought to be risk factors for CVD, surprisingly revealed a negative association between Hsp60 and seropositivity, suggesting a protective effect of this circulating stress protein.

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