Open AccessProtective Effect of Human Heat Shock Protein 60 Suggested by Its Association with Decreased Seropositivity to Pathogens
Author(s) -
Andrew Steptoe,
Alireza ShamaeiTousi,
Åsa Gylfe,
Leslie Bailey,
Sven Bergström,
Anthony R. M. Coates,
Brian E. Henderson
Publication year - 2007
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.00179-06
Subject(s) - hsp60 , heat shock protein , shock (circulatory) , immunology , disease , association (psychology) , biology , medicine , hsp70 , psychology , biochemistry , gene , psychotherapist
The presence of heat shock protein 60 (Hsp60) in human plasma has been linked with cardiovascular disease (CVD). In this study, the examination of the relationship between Hsp60 in plasma and seropositivity for three microbial agents, which are thought to be risk factors for CVD, surprisingly revealed a negative association between Hsp60 and seropositivity, suggesting a protective effect of this circulating stress protein.