Recombinant Sindbis Virus Vectors Designed To Express Protective Antigen of Bacillus anthracis Protect Animals from Anthrax and Display Synergy with Ciprofloxacin | Zendy

John Thomas | Zendy; Scott T. Moen | Zendy; Bryan T. Gnade | Zendy; Diego A. VargasInchaustegui | Zendy; Sheri M. Foltz | Zendy; Giovanni Suárez | Zendy; Hans W. Heidner | Zendy; Rolf König | Zendy; Ashok K. Chopra | Zendy; Johnny W. Peterson | Zendy

Open Access

Recombinant Sindbis Virus Vectors Designed To Express Protective Antigen of Bacillus anthracis Protect Animals from Anthrax and Display Synergy with Ciprofloxacin

Author(s) -

John Thomas,

Scott T. Moen,

Bryan T. Gnade,

Diego A. VargasInchaustegui,

Sheri M. Foltz,

Giovanni Suárez,

Hans W. Heidner,

Rolf König,

Ashok K. Chopra,

Johnny W. Peterson

Publication year - 2009

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00173-09

Subject(s) - bacillus anthracis , virology , sindbis virus , anthrax vaccines , recombinant dna , microbiology and biotechnology , biology , vaccination , antibody , antigen , immunogenicity , immunization , immunology , bacteria , dna vaccination , rna , biochemistry , genetics , gene

Recombinant Sindbis viruses were engineered to express alternative forms of the protective antigen (PA) ofBacillus anthracis . The recombinant viruses induced PA-specific immunoglobulin G and neutralizing antibodies in Swiss Webster mice. Vaccination with the recombinant viruses induced immunity that offered some protection from a lethal Ames strain spore challenge and synergized the protective effects of ciprofloxacin.

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