Open AccessRecombinant Sindbis Virus Vectors Designed To Express Protective Antigen of Bacillus anthracis Protect Animals from Anthrax and Display Synergy with Ciprofloxacin
Author(s) -
John Thomas,
Scott T. Moen,
Bryan T. Gnade,
Diego A. Vargas-Inchaustegui,
Sheri M. Foltz,
Giovanni Suárez,
Hans W. Heidner,
Rolf König,
Ashok K. Chopra,
Johnny W. Peterson
Publication year - 2009
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.00173-09
Subject(s) - bacillus anthracis , virology , sindbis virus , anthrax vaccines , recombinant dna , microbiology and biotechnology , biology , vaccination , antibody , antigen , immunogenicity , immunization , immunology , bacteria , dna vaccination , rna , biochemistry , genetics , gene
Recombinant Sindbis viruses were engineered to express alternative forms of the protective antigen (PA) ofBacillus anthracis . The recombinant viruses induced PA-specific immunoglobulin G and neutralizing antibodies in Swiss Webster mice. Vaccination with the recombinant viruses induced immunity that offered some protection from a lethal Ames strain spore challenge and synergized the protective effects of ciprofloxacin.