Mycobacterium tuberculosis Malate Synthase- and MPT51-Based Serodiagnostic Assay as an Adjunct to Rapid Identification of Pulmonary Tuberculosis | Zendy

Jacqueline M. Achkar | Zendy; Yuxin Dong | Zendy; Robert S. Holzman | Zendy; John T. Belisle | Zendy; Irene S. Kourbeti | Zendy; Tsering Sherpa | Zendy; Rany Condos | Zendy; William N. Rom | Zendy; Suman Laal | Zendy

Open Access

Mycobacterium tuberculosis Malate Synthase- and MPT51-Based Serodiagnostic Assay as an Adjunct to Rapid Identification of Pulmonary Tuberculosis

Author(s) -

Jacqueline M. Achkar,

Yuxin Dong,

Robert S. Holzman,

John T. Belisle,

Irene S. Kourbeti,

Tsering Sherpa,

Rany Condos,

William N. Rom,

Suman Laal

Publication year - 2006

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00158-06

Subject(s) - malate synthase , adjunct , tuberculosis , mycobacterium tuberculosis , pulmonary tuberculosis , microbiology and biotechnology , medicine , virology , immunology , biology , enzyme , pathology , biochemistry , linguistics , philosophy , glyoxylate cycle , isocitrate lyase

The 81-kDa malate synthase (MS; Rv 1837c) and the 27-kDa MPT51 (Rv 3803c) ofMycobacterium tuberculosis are immunodominant antigens recognized by serum antibodies from ∼80% of human immunodeficiency virus-negative smear-positive tuberculosis patients from India. We now provide evidence that the use of the MS/MPT51-based serodiagnostic assay can serve as an adjunct to sputum microscopy in the rapid diagnosis of pulmonary tuberculosis.

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