Evaluation of Helicobacter pylori Immunoglobulin G (IgG), IgA, and IgM Serologic Testing Compared to Stool Antigen Testing | Zendy

Rosemary C. She | Zendy; Andrew Wilson | Zendy; Christine M. Litwin | Zendy

Open Access

Evaluation of Helicobacter pylori Immunoglobulin G (IgG), IgA, and IgM Serologic Testing Compared to Stool Antigen Testing

Author(s) -

Rosemary C. She,

Andrew Wilson,

Christine M. Litwin

Publication year - 2009

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00149-09

Subject(s) - serology , helicobacter pylori , immunoglobulin a , immunoglobulin g , immunoglobulin m , immunology , antigen , antibody , medicine , gastroenterology

The utility of Helicobacter pylori serology was evaluated in 4,722 specimens and compared to stool antigen detection. Immunoglobulin M (IgM) sensitivity (6.8%) was unacceptably low. Key performance differences were observed in IgG specificity, IgA sensitivity, and specificity between adults and children that may warrant differentiating optimal serologic cutoff values by age.

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