Open AccessDisappearance of Vaccine-Type Invasive Pneumococcal Disease and Emergence of Serotype 19A in a Minority Population with a High Prevalence of Human Immunodeficiency Virus and Low Childhood Immunization Rates
Author(s) -
Azadeh Tasslimi,
Erica J. Sison,
Elizabeth Story,
David Alland,
Michele Burday,
Susan Morrison,
Sandhya Nalmas,
Stephen W. Smith,
Pauline Thomas,
Peter Wenger,
Anushua Sinha
Publication year - 2009
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.00140-09
Subject(s) - immunization , pneumococcal disease , serotype , pneumococcal vaccine , medicine , virology , population , epidemiology , disease , immunology , streptococcus pneumoniae , biology , environmental health , antibody , microbiology and biotechnology , antibiotics
We analyzed the epidemiology of invasive pneumococcal disease (IPD) following introduction of pneumococcal conjugated vaccine in an urban population with a 2% human immunodeficiency virus (HIV) prevalence and history of low childhood immunization rates. We observed near-elimination of vaccine-type IPD. Substantial disease remains due to non-vaccine-type pneumococci, highlighting the need to increase pneumococcal immunization among HIV-infected adults.