Open AccessInnate Immune Response toAnaplasma phagocytophilumContributes to Hepatic Injury
Author(s) -
Diana G. Scorpio,
Friederike D. von Loewenich,
Heike Göbel,
Christian Bogdan,
J. Stephen Dumler
Publication year - 2006
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.00092-06
Subject(s) - anaplasma phagocytophilum , tumor necrosis factor alpha , anaplasma , innate immune system , immunology , biology , toll like receptor , immune system , inflammation , virology , antibody , tick , borrelia burgdorferi
In mice,Anaplasma phagocytophilum control is independent of phagocyte oxidase (phox), inducible NO synthase (NOS2), tumor necrosis factor (TNF), and MyD88 Toll-like receptor signaling. We show that despite evasion of these host responses, phox, NOS2, TNF, and MyD88 are activated and contribute to inflammation and hepatic injury more thanA. phagocytophilum itself.