Macrophage Depletion Prior to Neospora caninum Infection Results in Severe Neosporosis in Mice | Zendy

Chisa Abe | Zendy; Sachi Tanaka | Zendy; Fumiaki Ihara | Zendy; Yoshifumi Nishikawa | Zendy

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Macrophage Depletion Prior to Neospora caninum Infection Results in Severe Neosporosis in Mice

Author(s) -

Chisa Abe,

Sachi Tanaka,

Fumiaki Ihara,

Yoshifumi Nishikawa

Publication year - 2014

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00082-14

Subject(s) - neospora caninum , macrophage , neospora , interferon gamma , immunity , biology , immunology , virology , microbiology and biotechnology , immune system , antibody , in vitro , biochemistry , toxoplasma gondii

We observed that murine macrophages showed greater activation and increased interleukin 6 (IL-6), IL-12p40, and interferon gamma (IFN-γ) production during Neospora caninum infection. Many macrophages migrated to the site of infection. Furthermore, macrophage-depleted mice exhibited increased sensitivity to N. caninum infection. This study indicates that macrophages are required for achieving protective immunity against N. caninum .

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