Open AccessDiagnosis of Tuberculous Meningitis Due to Detection of ESAT-6-Specific Gamma Interferon Production in Cerebrospinal Fluid Enzyme-Linked Immunospot Assay
Author(s) -
Shuji Murakami,
Mitsuhiro Takeno,
Hideaki Oka,
Atsushi Ueda,
Takashi Kurokawa,
Yoshihiro Kuroiwa,
Yoshiaki Ishigatsubo
Publication year - 2008
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.00029-08
Subject(s) - cerebrospinal fluid , meningitis , tuberculous meningitis , medicine , immunology , interferon gamma , tuberculosis , virology , microbiology and biotechnology , pathology , biology , cytokine , psychiatry
A coma patient was diagnosed with tuberculous meningitis by the detection of ESAT-6-specific gamma interferon-secreting cells in the patient's cerebrospinal fluid by enzyme-linked immunospot assay prior to the identification of the pathogen in a culture of the cerebrospinal fluid.