Improved Skin Test for Differential Diagnosis of Bovine Tuberculosis by the Addition of Rv3020c-Derived Peptides | Zendy

Gareth J. Jones | Zendy; Adam O. Whelan | Zendy; Derek Clifford | Zendy; Mick Coad | Zendy; H. Martin Vordermeier | Zendy

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Improved Skin Test for Differential Diagnosis of Bovine Tuberculosis by the Addition of Rv3020c-Derived Peptides

Author(s) -

Gareth J. Jones,

Adam O. Whelan,

Derek Clifford,

Mick Coad,

H. Martin Vordermeier

Publication year - 2012

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00024-12

Subject(s) - mycobacterium bovis , diva , antigen , vaccination , tuberculosis , bcg vaccine , virology , mycobacterium tuberculosis , skin test , microbiology and biotechnology , biology , medicine , immunology , pathology

A peptide cocktail derived from the mycobacterial antigens ESAT-6, CFP-10, and Rv3615c allowed differentiation between Mycobacterium bovis -infected and M. bovis bacillus Calmette-Guérin (BCG)-vaccinated cattle when used as a skin test reagent for a “DIVA” test (i.e., a test capable of d ifferentiating i nfected and uninfected v accinated a nimals). Addition of the antigen Rv3020c improves the diagnostic sensitivity without compromising specificity in the face of BCG or Johne's disease vaccination.

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