Open AccessImmunoglobulin G Avidities in Infants in Mexico after Primary Immunization with Three Doses of Polyribosylribitol Phosphate-Tetanus ToxoidHaemophilus influenzaeType b Vaccine
Author(s) -
Patricia Gómez-de-León,
Francisco Javier Díaz-García,
Alberto Villaseñor-Sierra,
J Segura,
Martha I. Carranza,
José Luis Arredondo-Garcı́a,
José Ignacio Santos
Publication year - 2008
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.00009-08
Subject(s) - tetanus , toxoid , hib vaccine , diphtheria , vaccination , haemophilus influenzae , immunization , medicine , antibody , haemophilus , immunoglobulin g , immunology , virology , microbiology and biotechnology , biology , conjugate vaccine , bacteria , antibiotics , genetics
Serum immunoglobulin G concentrations and avidities specific toHaemophilus influenzae type b (Hib) were measured in 208 children living in Guadalajara and Mexico City. Protective concentrations were found in 98.9% and 100.0% of participants, respectively. Geometric mean concentrations differed between both populations and/or among age groups. Mean avidities differed only among the 7- to 12-month-old children. Diphtheria-tetanus-whole-cell pertussis-hepatitis B-Hib primary vaccination seems to induce protection in Mexican children.