Role of dendritic cells in immunopathogenesis of human immunodeficiency virus infection | Zendy

D Weissman | Zendy; A S Fauci | Zendy

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Role of dendritic cells in immunopathogenesis of human immunodeficiency virus infection

Author(s) -

D Weissman,

A S Fauci

Publication year - 1997

Publication title -

clinical microbiology reviews

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.177

H-Index - 282

eISSN - 1070-6305

pISSN - 0893-8512

DOI - 10.1128/cmr.10.2.358

Subject(s) - immunology , human immunodeficiency virus (hiv) , pathogenesis , virology , immunopathology , virus , disease , viral replication , immunodeficiency , viral disease , biology , medicine , immune system , pathology

The role of dendritic cells (DC) in the pathogenesis of human immunodeficiency virus (HIV) disease has been a subject of considerable interest for several years. Initial studies focused on the infection, dysfunction, and depletion of DC in HIV-infected individuals. More recent studies have begun to identify the functional role of DC in the initiation and propagation of viral replication in T cells in HIV-infected individuals. This review discusses recent data regarding the role of DC in HIV disease with the aim of delineating basic immunopathogenic principles of infection and the development of therapeutic strategies.

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