Host-Directed Antiviral Therapy | Zendy

Naveen Kumar | Zendy; Shalini Sharma | Zendy; Ram Kumar | Zendy; Bhupendra Nath Tripathi | Zendy; Sanjay Barua | Zendy; Hinh Ly | Zendy; Barry T. Rouse | Zendy

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Host-Directed Antiviral Therapy

Author(s) -

Naveen Kumar,

Shalini Sharma,

Ram Kumar,

Bhupendra Nath Tripathi,

Sanjay Barua,

Hinh Ly,

Barry T. Rouse

Publication year - 2020

Publication title -

clinical microbiology reviews

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.177

H-Index - 282

eISSN - 1070-6305

pISSN - 0893-8512

DOI - 10.1128/cmr.00168-19

Subject(s) - kinome , crispr , biology , computational biology , small interfering rna , palindrome , viral replication , genome , virology , antiviral therapy , small molecule , rna interference , rna , drug discovery , virus , genetics , bioinformatics , kinase , gene , chronic hepatitis

Antiviral drugs have traditionally been developed by directly targeting essential viral components. However, this strategy often fails due to the rapid generation of drug-resistant viruses. Recent genome-wide approaches, such as those employing small interfering RNA (siRNA) or clustered regularly interspaced short palindromic repeats (CRISPR) or those using small molecule chemical inhibitors targeting the cellular “kinome,” have been used successfully to identify cellular factors that can support virus replication.

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