Open AccessPerformance of Two Commercial Glycoprotein G-Based Enzyme Immunoassays for Detecting Antibodies to Herpes Simplex Viruses 1 and 2 in Children and Young Adolescents
Author(s) -
Charles T. Leach,
Rhoda Ashley,
Jacques Baillargeon,
Hal B. Jenson
Publication year - 2002
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cdli.9.5.1124-1125.2002
Subject(s) - herpes simplex virus , hsl and hsv , virology , antibody , alphaherpesvirinae , herpesviridae , simplexvirus , enzyme , glycoprotein , herpes genitalis , biology , virus , immunology , genital herpes , microbiology and biotechnology , viral disease , biochemistry
In 61 patients 1 to 14 years of age, the Gull/Meridian enzyme-linked immunosorbent assay (ELISA) had a sensitivity of 100% for herpes simplex virus type 1 (HSV-1) and specificities of 74% for HSV-1 and 48% for HSV-2. In 128 similarly aged patients, the HerpeSelect ELISA (Focus Technologies) showed sensitivities of 80% for HSV-1 and 88% for HSV-2, and specificities of 97% for HSV-1 and 100% for HSV-2.