Performance of Two Commercial Glycoprotein G-Based Enzyme Immunoassays for Detecting Antibodies to Herpes Simplex Viruses 1 and 2 in Children and Young Adolescents | Zendy

Charles T. Leach | Zendy; Rhoda L. Ashley | Zendy; Jacques Baillargeon | Zendy; Hal B. Jenson | Zendy

Open Access

Performance of Two Commercial Glycoprotein G-Based Enzyme Immunoassays for Detecting Antibodies to Herpes Simplex Viruses 1 and 2 in Children and Young Adolescents

Author(s) -

Charles T. Leach,

Rhoda L. Ashley,

Jacques Baillargeon,

Hal B. Jenson

Publication year - 2002

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cdli.9.5.1124-1125.2002

Subject(s) - herpes simplex virus , hsl and hsv , virology , antibody , alphaherpesvirinae , herpesviridae , simplexvirus , enzyme , glycoprotein , herpes genitalis , biology , virus , immunology , genital herpes , microbiology and biotechnology , viral disease , biochemistry

In 61 patients 1 to 14 years of age, the Gull/Meridian enzyme-linked immunosorbent assay (ELISA) had a sensitivity of 100% for herpes simplex virus type 1 (HSV-1) and specificities of 74% for HSV-1 and 48% for HSV-2. In 128 similarly aged patients, the HerpeSelect ELISA (Focus Technologies) showed sensitivities of 80% for HSV-1 and 88% for HSV-2, and specificities of 97% for HSV-1 and 100% for HSV-2.

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