Open AccessInfluence of Host Factors on Immunoglobulin G Concentration in Oral Fluid Specimens
Author(s) -
Timothy C. Granade,
Susan Phillips,
Wendy Kitson-Piggott,
Perry Gomez,
Bisram Mahabir,
Herbert Oleander,
J. Richard George,
James Baggs,
Bharat Parekh
Publication year - 2002
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cdli.9.1.194-197.2002
Subject(s) - medicine , immunoglobulin g , antibody , univariate analysis , specific antibody , human immunodeficiency virus (hiv) , immunology , multivariate analysis
The influence of host factors (tobacco use, dentition, bleeding gums, oral rinsing, nasal medications, and time since the last meal) on immunoglobulin G (IgG) concentration in oral fluids (OF) was determined by univariate and multivariate analysis. Significant differences in IgG concentration were found to be associated with human immunodeficiency virus (HIV) status (HIV antibody positive, +16.60 microg/ml, P = 0.0001), sex (female, +1.23 microg/ml, P = 0.004), dentition (+2.83 microg/ml, edentulous versus dentulous, P = 0.0001), bleeding gums (+6.35 microg/ml, P = 0.0001), and time since the last meal (+3.55 microg/ml, >6 h, P = 0.0001). These factors could impact diagnostic methods that rely on the immunoglobulin concentration in OF specimens.