Open AccessCorrelation of CD4 + T-Cell Counts Estimated by an Immunocapture Technique (Capcellia) with Viral Loads in Human Immunodeficiency Virus-Seropositive Individuals
Author(s) -
Rajesh Kannangai,
Sandeep Ramalingam,
Mary V. Jesudason,
T. Vijayakumar,
O C Abraham,
Anand Zachariah,
Gopalan Sridharan
Publication year - 2001
Publication title -
clinical and diagnostic laboratory immunology
Language(s) - English
Resource type - Journals
eISSN - 1098-6588
pISSN - 1071-412X
DOI - 10.1128/cdli.8.6.1286-1288.2001
Subject(s) - viral load , flow cytometry , human immunodeficiency virus (hiv) , virology , viral disease , lentivirus , virus , immunology , correlation , immunopathology , sida , biology , medicine , mathematics , geometry
As antiretroviral therapy becomes more affordable, valid, reliable, and inexpensive laboratory tests are also needed to monitor the progression of disease in people with human immunodeficiency virus (HIV) infection. The CD4(+) T-cell counts estimated by Capcellia, an immunocapture method, and flow cytometry were compared and were correlated with HIV type 1 (HIV-1) load. There was a significant negative correlation between the HIV-1 load and CD4(+) T-cell counts estimated by flow cytometry (r = -0.63, P = <0.001) as well as between the HIV-1 load and CD4(+) T-cell counts estimated by Capcellia (r = -0.61, P = <0.001). Capcellia is a cost-effective, user-friendly assay that correlated well with HIV-1 load determinations for individuals both with and without treatment.