Open AccessInhibition of Ganciclovir-Susceptible and -Resistant Human Cytomegalovirus Clinical Isolates by the Benzimidazole l -Riboside 1263W94
Author(s) -
James J. McSharry,
Ann McDonough,
Betty Olson,
Christine L. Talarico,
M. R. Davis,
Karen K. Biron
Publication year - 2001
Publication title -
clinical and diagnostic laboratory immunology
Language(s) - English
Resource type - Journals
eISSN - 1098-6588
pISSN - 1071-412X
DOI - 10.1128/cdli.8.6.1279-1281.2001
Subject(s) - ganciclovir , human cytomegalovirus , virology , cytomegalovirus , benzimidazole , biology , microbiology and biotechnology , herpesviridae , chemistry , virus , viral disease , organic chemistry
The average 50% inhibitory concentration (IC(50)) values for AD169 were 0.22 +/- 0.09 microM 1263W94 and 5.36 +/- 0.12 microM ganciclovir. For 35 human cytomegalovirus (HCMV) clinical isolates the average IC(50) was 0.42 +/- 0.09 microM 1263W94, and for 26 ganciclovir-susceptible HCMV clinical isolates the average IC(50) was 3.78 +/- 1.62 microM ganciclovir. Nine HCMV clinical isolates that were resistant to ganciclovir were completely susceptible to 1263W94.