Identification of Potentially DiagnosticLeishmania braziliensisAntigens in Human Cutaneous Leishmaniasis by Immunoblot Analysis | Zendy

Maria Edileuza Felinto de Brito | Zendy; Mitzi G. Mendonça | Zendy; Yara M. Gomes | Zendy; Márcio Lobo Jardim | Zendy; Frederico G. C. Abath | Zendy

Open Access

Identification of Potentially DiagnosticLeishmania braziliensisAntigens in Human Cutaneous Leishmaniasis by Immunoblot Analysis

Author(s) -

Maria Edileuza Felinto de Brito,

Mitzi G. Mendonça,

Yara M. Gomes,

Márcio Lobo Jardim,

Frederico G. C. Abath

Publication year - 2000

Publication title -

clinical and diagnostic laboratory immunology

Language(s) - English

Resource type - Journals

eISSN - 1098-6588

pISSN - 1071-412X

DOI - 10.1128/cdli.7.2.318-321.2000

Subject(s) - cutaneous leishmaniasis , antigen , leishmania braziliensis , leishmaniasis , leishmania , immunofluorescence , indirect immunofluorescence , biology , antibody , immunology , virology , microbiology and biotechnology , parasite hosting , world wide web , computer science

The antibody response in patients with American cutaneous leishmaniasis was analyzed by immunoblotting with soluble and insoluble antigens ofLeishmania braziliensis . The recognition of the 27- and/or 30-kDa soluble antigens was considered relevant for the diagnosis of cutaneous leishmaniasis. Immunoblotting was found to be significantly more sensitive and specific than indirect immunofluorescence and enzyme-linked immunosorbent assay.

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