Protection against Influenza Virus Infection of Mice Fed Bifidobacterium breve YIT4064 | Zendy

Hisako Yasui | Zendy; Junko Kiyoshima | Zendy; T Hori | Zendy; Kan Shida | Zendy

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Protection against Influenza Virus Infection of Mice Fed Bifidobacterium breve YIT4064

Author(s) -

Hisako Yasui,

Junko Kiyoshima,

T Hori,

Kan Shida

Publication year - 1999

Publication title -

clinical and diagnostic laboratory immunology

Language(s) - English

Resource type - Journals

eISSN - 1098-6588

pISSN - 1071-412X

DOI - 10.1128/cdli.6.2.186-192.1999

Subject(s) - virus , virology , bifidobacterium breve , immunization , antigen , antibody , oral administration , influenza a virus , medicine , microbiology and biotechnology , immunology , biology , bifidobacterium , bacteria , pharmacology , lactobacillus , genetics

Mice fedBifidobacterium breve YIT4064 and immunized orally with influenza virus were more strongly protected against influenza virus infection of the lower respiratory tract than ones immunized with influenza virus only. The number of mice with enhanced anti-influenza virus immunoglobulin G (IgG) in serum upon oral administration ofB. breve YIT4064 and oral immunization with influenza virus was significantly greater than that upon oral immunization with influenza virus only. These findings demonstrated that the oral administration ofB. breve YIT4064 increased anti-influenza virus IgG antibodies in serum and protected against influenza virus infection. The oral administration ofB. breve YIT4064 may enhance antigen-specific IgG against various pathogenic antigens taken orally and induce protection against various virus infections.

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