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trans -Sialidase inhibition assay (TIA) was employed in a population at high risk ofTrypanosoma cruzi infection. From 20 serum samples that were negative by conventional serologic and parasitologic assays, 18 (90%) were reactive in TIA, providing further evidence of the higher sensitivity of TIA and suggesting that the actual prevalence ofT. cruzi infection might be underestimated.

Use of trans -Sialidase Inhibition Assay in a Population Serologically Negative for Trypanosoma cruzi but at a High Risk of Infection