Influence of different conditions on kinetics of tumor necrosis factor alpha release by peripheral blood mononuclear cells after stimulation with Cryptococcus neoformans: a possible explanation for different results | Zendy

Wendy Chaka | Zendy; A F Verheul | Zendy; Andy I. M. Hoepelman | Zendy

Open Access

Influence of different conditions on kinetics of tumor necrosis factor alpha release by peripheral blood mononuclear cells after stimulation with Cryptococcus neoformans: a possible explanation for different results

Author(s) -

Wendy Chaka,

A F Verheul,

Andy I. M. Hoepelman

Publication year - 1997

Publication title -

clinical and diagnostic laboratory immunology

Language(s) - English

Resource type - Journals

eISSN - 1098-6588

pISSN - 1071-412X

DOI - 10.1128/cdli.4.6.792-794.1997

Subject(s) - peripheral blood mononuclear cell , cryptococcus neoformans , tumor necrosis factor alpha , stimulation , kinetics , immunology , peripheral blood , cryptococcus , chemistry , alpha (finance) , microbiology and biotechnology , biology , medicine , in vitro , biochemistry , endocrinology , physics , construct validity , nursing , patient satisfaction , quantum mechanics

In available literature, different kinetics for tumor necrosis factor alpha (TNF-alpha) release by peripheral blood mononuclear cells are reported upon stimulation with Cryptococcus neoformans. Results in this study showed that shaking cells gives faster kinetics of TNF-alpha release while large working volumes give lower TNF-alpha concentrations. Different experimental conditions thus influence kinetics of TNF-alpha release by phagocytes.

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