Open AccessAntibody production against hepatitis C virus core and nonstructural 3 proteins is highly sensitive to deficits in T-cell function
Author(s) -
Yasumasa Ando,
Anders Sönnerborg,
Lisbeth Barkholt,
Ashley Birkett,
BoGöran Ericzon,
Matti Sällberg
Publication year - 1997
Publication title -
clinical and diagnostic laboratory immunology
Language(s) - English
Resource type - Journals
eISSN - 1098-6588
pISSN - 1071-412X
DOI - 10.1128/cdli.4.1.104-106.1997
Subject(s) - hepatitis c virus , antibody , virology , virus , ns2 3 protease , cd8 , ns3 , biology , humoral immunity , function (biology) , immune system , immunology , microbiology and biotechnology
The influence of suppression of CD4+ and CD8+ T cells on the humoral responses to hepatitis C virus (HCV) core and nonstructural 3 proteins was studied. An increasing viral burden cannot substitute for the lack of functional T cells in maintaining humoral HCV-specific responses.