Antibody production against hepatitis C virus core and nonstructural 3 proteins is highly sensitive to deficits in T-cell function | Zendy

Yukio Ando | Zendy; Anders Sönnerborg | Zendy; Lisbeth Barkholt | Zendy; Ashley J. Birkett | Zendy; BoGöran Ericzon | Zendy; Matti Sällberg | Zendy

Open Access

Antibody production against hepatitis C virus core and nonstructural 3 proteins is highly sensitive to deficits in T-cell function

Author(s) -

Yukio Ando,

Anders Sönnerborg,

Lisbeth Barkholt,

Ashley J. Birkett,

BoGöran Ericzon,

Matti Sällberg

Publication year - 1997

Publication title -

clinical and diagnostic laboratory immunology

Language(s) - English

Resource type - Journals

eISSN - 1098-6588

pISSN - 1071-412X

DOI - 10.1128/cdli.4.1.104-106.1997

Subject(s) - hepatitis c virus , virology , antibody , cd8 , virus , biology , humoral immunity , ns3 , function (biology) , immunology , ns2 3 protease , immune system , microbiology and biotechnology

The influence of suppression of CD4+ and CD8+ T cells on the humoral responses to hepatitis C virus (HCV) core and nonstructural 3 proteins was studied. An increasing viral burden cannot substitute for the lack of functional T cells in maintaining humoral HCV-specific responses.

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