Open AccessUtilization of Follow-Up Specimens from Viremic Blood Donors To Assess the Value of West Nile Virus Immunoglobulin G Avidity as an Indicator of Recent Infection
Author(s) -
Harry E. Prince,
Mary Lapé-Nixon,
Michael P. Busch,
Leslie H. Tobler,
Gregory A. Foster,
Susan L. Stramer
Publication year - 2005
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cdli.12.9.1123-1126.2005
Subject(s) - avidity , west nile virus , virology , antibody , immunoglobulin m , immunology , immunoglobulin g , virus , biology , medicine
The value of West Nile virus immunoglobulin G avidity for distinguishing recent from past infection was investigated using 348 follow-up specimens from 170 viremic blood donors. Low avidity accurately indicated infection within the previous 4 months. However, due to rapid avidity maturation in some individuals, high avidity did not accurately indicate past infection.