Open AccessOpsonization Effects on Mycobacterium avium subsp. paratuberculosis -Macrophage Interactions
Author(s) -
Jesse M. Hostetter,
Rhoda Kagan,
Edward M. Steadham
Publication year - 2005
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cdli.12.6.793-796.2005
Subject(s) - paratuberculosis , antibody opsonization , mycobacterium avium subsp. paratuberculosis , macrophage , microbiology and biotechnology , opsonin , mycobacterium , biology , antibody , immunology , virology , bacteria , in vitro , biochemistry , genetics
High antibody titers in ruminants infected with Mycobacterium avium subsp. paratuberculosis correlates with disease progression. Effects of humoral responses during mycobacterial infection are not completely understood. This study suggests that activation status may be an important factor in determining macrophage ability to limit proliferation of opsonized M. avium subsp. paratuberculosis.