Interlaboratory Reliability of Microimmunofluorescence Test for Measurement of Chlamydia pneumoniae -Specific Immunoglobulin A and G Antibody Titers | Zendy

Alyson J. Littman | Zendy; Lisa A. Jackson | Zendy; Emily White | Zendy; Mark Thornquist | Zendy; Charlotte A. Gaydos | Zendy; Thomas L. Vaughan | Zendy

Open Access

Interlaboratory Reliability of Microimmunofluorescence Test for Measurement of Chlamydia pneumoniae -Specific Immunoglobulin A and G Antibody Titers

Author(s) -

Alyson J. Littman,

Lisa A. Jackson,

Emily White,

Mark Thornquist,

Charlotte A. Gaydos,

Thomas L. Vaughan

Publication year - 2004

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cdli.11.3.615-617.2004

Subject(s) - chlamydia , chlamydophila pneumoniae , immunology , antibody , titer , chlamydiaceae , immunoglobulin g , antibody titer , immunoglobulin a , immunoglobulin m , chlamydiales , biology , medicine

To evaluate the reliability of Chlamydia pneumoniae-specific immunoglobulin G (IgG) and IgA antibody titers as measured by the microimmunofluorescence (MIF) test, we compared results from 392 individuals using a standard MIF protocol at two academic laboratories. The kappas for dichotomous titers (>/=16 versus <16) were 0.39 for IgA and 0.53 for IgG. Measurement error likely attenuates C. pneumoniae-disease associations; the magnitude of attenuation can be estimated from results of studies such as this one.

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