Performance Characteristics of a Rapid New Immunochromatographic Test for Detection of Antibodies to Human Immunodeficiency Virus | Zendy

Rodrigo RibeiroRodrigues | Zendy; Lauro Ferreira da Silva Pinto Neto | Zendy; Carla B. Cunha | Zendy; Valéria P. Cabral | Zendy; Reynaldo Dietze | Zendy

Open Access

Performance Characteristics of a Rapid New Immunochromatographic Test for Detection of Antibodies to Human Immunodeficiency Virus

Author(s) -

Rodrigo RibeiroRodrigues,

Lauro Ferreira da Silva Pinto Neto,

Carla B. Cunha,

Valéria P. Cabral,

Reynaldo Dietze

Publication year - 2003

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cdli.10.2.303-307.2003

Subject(s) - human immunodeficiency virus (hiv) , antibody , human plasma , virology , medicine , human blood , blot , immunology , chromatography , chemistry , physiology , biochemistry , gene

A new immunochromatographic rapid test (Rapid Check HIV 1 and 2; Núcleo de Doenças Infecciosas) for the detection of antibodies to human immunodeficiency virus type 1 and type 2 in human samples (whole blood, serum, and plasma) was evaluated and compared to the commercially available Determine (Abbott Laboratories). When whole-blood samples were evaluated, the specificity and sensitivity of both tests were 100%. However, when plasma samples were used, sensitivity for the Rapid Check HIV 1&2 and the Determine tests were 100 and 98.58%, respectively. The observed specificity for plasma samples was 98.94% for the Rapid Check HIV 1&2 and 96.97% for the Determine test. The results presented here are encouraging and support the adoption of both tests as an alternative to enzyme-lined immunosorbent assay and/or Western blots in regions where laboratorial infrastructure is not available or for use in the management of occupational accidents for healthcare workers.

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