Open AccessDetection of Low-Avidity Immunoglobulin G in Oral Fluid Samples: New Approach for Rubella Diagnosis and Surveillance
Author(s) -
D. Akingbade,
B. J. Cohen,
David Brown
Publication year - 2003
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cdli.10.1.189-190.2003
Subject(s) - avidity , rubella , immunology , antibody , immunoglobulin g , immunoglobulin m , medicine , predictive value , virology , vaccination , measles
Low-avidity rubella immunoglobulin G (IgG) was detected in oral fluid samples from 30 of 32 rubella IgM-positive patients (sensitivity, 94%) and from 4 of 34 IgM-negative patients (specificity, 88%). Measuring IgG avidity in oral fluid samples could improve the reliability of rubella surveillance when the incidence of the disease and the positive predictive value of IgM tests are low.